When cells are healthy, we don't expect them to suddenly change cell types. A skin cell on your hand won't naturally morph into a brain cell, and vice versa. That's thanks to epigenetic memory, which ...

Investigators led by Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how the metabolism of mitochondria supports ...

An international research team led jointly by the University Medical Center Göttingen (UMG), the University of Göttingen and ...

We then compared the phenotype of P14 T cells and examined expression of the memory T cell-associated molecule, CD127, along with a TE cell- and t-T EM cell/LLEC-associated molecule, KLRG1. Consistent ...

For decades, dogma dictated that the immune system consisted of two separate branches. Cells of the innate system respond rapidly to molecular patterns shared by a broad array of pathogens. Meanwhile, ...

The Israeli study examined tumor samples and nearby lymph nodes from 11 patients with high-grade serous ovarian cancer.

However, details of the intervening steps, as researchers have learned in the past 65 years, are quite complex — certain cells carry the flu antigen to the immune system, specific immune cells respond ...

B cells play a key role in humoral immune responses through their ability to produce antibodies. In addition, they can also function through other antibody-independent pathways, such as immune ...

Research from Radboud University Medical Center reveals that T cells from the adaptive immune system can manipulate the memory of innate immune cells. Previously, it was believed that the memory of ...

CAR T-cell therapy has transformed the treatment of hematologic malignancies, yet many patients do not achieve lasting benefit – often because the infused cells fail to expand or persist. This study ...

Chimeric antigen receptor (CAR) T cells have a tough job. Engineered with a receptor that recognizes molecules decorating the surface of cancer cells, CAR T cells find and kill malignancies. However, ...

T-bet expression is required for persistence of memory B cells that have rapid differentiation potential to become antibody-producing plasma cells in response to a second infection BIRMINGHAM, Ala. – ...