Completing DNA replication triggers genomic instability in bacteria

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...
Nature

Automated mapping of DNA replication fork progression in human cells with ForkML

Current approaches to mapping fork progression in the human genome suffer from drastically low throughput. Here, we introduce ForkML, a nanopore sequencing-based method automatically positioning ...
Phys.org

DNA replication in early embryos differs from previous assumptions, study shows

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...
Nature

RF-SIRF reveals a replication stress-specific epigenetic code by spatio-temporal mapping of reversed forks

DNA replication stress responses are guardians of genomic stability critical during development, hematopoiesis, cancer therapy response, aging and disease suppression. Central to these responses are ...
techtimes

Wisconsin Researchers Map Bacterial DNA Repair Restart, Revealing New Antibiotic Targets

Structural biologists at the University of Wisconsin-Madison today published cryo-electron microscopy structures of the complete bacterial DNA replication restart complex — a molecular machine that ...