In cancer research, one person's junk is increasingly becoming another person's treasure. Scientists have uncovered new evidence showing how recently evolved "junk DNA" genetic elements can become ...

Using a system of genetic barcodes and a novel single-cell sequencing method, a research team at the Istituto Italiano di Tecnologia (IIT-Italian Institute of Technology) in Milan has developed an ...

Cancer does not develop overnight. It can take decades for cancer‐promoting changes in the genome to eventually lead to the formation of a malignant tumor. Researchers at the German Cancer Research ...

In cancer research, one person's junk is increasingly becoming another person's treasure. Scientists have now uncovered new evidence showing how recently evolved "junk DNA" genetic elements can become ...

The Human Tumor Atlas Network leverages scientific collaboration to integrate samples, analytical modalities and tools into detailed atlases of tumor evolution. Expanding our spatial understanding of ...

EVOFLUx uses DNA methylation fluctuations as molecular barcodes to trace tumor evolution, offering insights into growth, treatment resistance, and prognosis. The method requires only bulk methylation ...

A review examines the prevailing theory of cancer evolution. The authors highlight both practical and theoretical limitations of the clonal model of cancer evolution and propose areas for improving ...

Digestive system cancers, including hepatobiliary and gastrointestinal malignancies, remain a major global oncological burden ...

Serial circulating tumor DNA analysis can demonstrate rapid clonal dynamics that evolve during response and resistance to both standard chemotherapy and targeted therapy of BRAF-mutant colon cancer ...

Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition associated with increased mortality among patients with cancer. CHIP mutations with high variant-allele frequencies ...

Growing support for perioperative vs neoadjuvant therapy, but many questions yet to be ans ...